N-[(5-氯-2-噻吩基)羰基]甘氨酸合成路线 （共 3 条）
反应条件
1: With methanol; lithium hydroxide; water in 1,4-dioxane
T=20°C; 2 h;
2: With hydrogenchloride
T=20°C; pH=7; 2 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/2099 A2, 2006 ;
Location in patent: Page/Page column 195 ;
WO 2006/002099 A2
反应条件
sodium hydroxide in water
T=20°C; 1 h;
参考文献
NB HEALTH LABORATORY CO., LTD.; PHARMADESIGN, INC.; Okamoto, Masako; Takayama, Kiyoshi
Patent: US2013/137730 A1, 2013 ;
Location in patent: Paragraph 0111-0112 ;
反应条件
1: thionyl chloride / benzene / 2 h / 105 °C
2: sodium hydroxide / water / 1 h / 20 °C
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参考文献
NB HEALTH LABORATORY CO., LTD.; PHARMADESIGN, INC.; Okamoto, Masako; Takayama, Kiyoshi
Patent: US2013/137730 A1, 2013 ;
