2-氯-4,5,7,8-四氢-6H-噻吩并[2,3-d]氮杂烷-6-羧酸叔丁酯合成路线 （共 5 条）
反应条件
N-(trimethylsilyl)-imidazole in chloroform T=70°C;
参考文献
Athersys, Inc.
Patent: US2006/3990 A1, 2006 ;
Location in patent: Page/Page column 15 ;
US 20060003990 A1
反应条件
1: With AlCl3, aluminium chloride; tBuNH2·BH3 in dichloromethane
T=0 - 20°C; 2.16667 h;
2: With hydrogenchloride in dichloromethane; water
参考文献
Athersys, Inc.
Patent: US2006/3990 A1, 2006 ;
Location in patent: Page/Page column 8; 15 ;
US 20060003990 A1
反应条件
1: 4,5,7,8-Tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester With potassium hydroxide
2: di-tert-butyl dicarbonate With sodium hydrogencarbonate
参考文献
Athersys, Inc.
Patent: US2006/3990 A1, 2006 ;
Location in patent: Page/Page column 8 ;
US 20060003990 A1
反应条件
N-bromosuccinmide; acetic acid in chloroform
T=20°C; 0.5 h;
参考文献
ATHERSYS, INC.
Patent: WO2007/84622 A2, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/084622 A2
反应条件
AlCl3, aluminium chloride in anhydrous dichloroethane
T=0°C; 0.5 h;
参考文献
ATHERSYS, INC.
Patent: WO2007/84622 A2, 2007 ;
Location in patent: Page/Page column 43-44 ;
WO 2007/084622 A2
