2,4-二-叔丁基-5-硝基苯酚合成路线 （共 6 条）
反应条件
hydrogenchloride; KOH in methanol
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With sulfuric acid; nitric acid in methanol
T=20 - 50°C; Cooling with ice;
2: With potassium hydroxide in methanol
T=20°C; 2 h;
3: With hydrogenchloride in methanol
pH=2 - 3;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2010/168094 A1, 2010 ;
Location in patent: Page/Page column 72; 73 ;
US 20100168094 A1
反应条件
1: sulfuric acid; nitric acid; sodium sulfate / hexane; water
2: hydrogenchloride; KOH / methanol
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane; water
2: nitric acid / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid
3: hydrogenchloride; KOH / methanol
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
ammonium formate; palladium on activated carbon in ethanol
2 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS, INC.
Patent: WO2007/79139 A2, 2007 ;
Location in patent: Page/Page column 47-49 ;
反应条件
ammonium formate in ethanol
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
