1: 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ester With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: 5-amino-2,4-di-tert-butyl-phenol in N,N-dimethyl-formamide T=20°C;

ammonium formate; palladium on activated carbon in ethanol 2 h; Heating / reflux;

ammonium formate in ethanol

1: sulfuric acid; nitric acid; sodium sulfate / hexane; water 2: hydrogenchloride; KOH / methanol 3: ammonium formate / ethanol View Scheme

1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane; water 2: nitric acid / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid 3: hydrogenchloride; KOH / methanol 4: ammonium formate / ethanol View Scheme

1: hydrogenchloride; KOH / methanol 2: ammonium formate / ethanol View Scheme