hydrogen; 30 Pd/C in ethanol T=20°C; 48 h;

sodium hydroxide in ethanol; water 2.5 h; Reflux;

1: borane-THF / tetrahydrofuran / 3 h / 0 °C 2: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 20 °C 3: pyridinium chlorochromate / dichloromethane / 2.5 h / 20 °C / Molecular sieve 4: potassium tert-butylate / ethylene glycol dimethyl ether; tert-butyl alcohol / 3.5 h / 0 - 20 °C 5: sodium hydroxide / ethanol; water / 2.5 h / Reflux View Scheme

1: pyridinium chlorochromate / dichloromethane / 2.5 h / 20 °C / Molecular sieve 2: potassium tert-butylate / ethylene glycol dimethyl ether; tert-butyl alcohol / 3.5 h / 0 - 20 °C 3: sodium hydroxide / ethanol; water / 2.5 h / Reflux View Scheme

1: potassium tert-butylate / ethylene glycol dimethyl ether; tert-butyl alcohol / 3.5 h / 0 - 20 °C 2: sodium hydroxide / ethanol; water / 2.5 h / Reflux View Scheme

sodium hydroxide Anschliessend Hydrierung an Raney-Nickel bei 150grad/250 at;