8-(（苯并[D][1,3]二氧杂环戊烯-6 - 基）甲基）- 9H-嘌呤-2,6 - 二胺合成路线 （共 5 条）
反应条件
1: With sodium hydroxide in water; N,N-dimethyl-formamide
T=20 - 70°C; 1.83333 h;
2: With sodium methylate in methanol
T=90°C; 18 h;
参考文献
Wyeth
Patent: US2008/96903 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
triphenyl phosphite; sodium t-butanolate in pyridine
T=220°C; P=6000.6 Torr; 0.25 h; Microwave irradiation;
参考文献
Tao, Hui; Kang, Yanlong; Taldone, Tony; Chiosis, Gabriela
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 415 - 417
反应条件
sodium methylate in ethanol
Heating;
参考文献
Dymock, Brian; Barril, Xavier; Beswick, Mandy; Collier, Adam; Davies, Nicholas; Drysdale, Martin; Fink, Alexandra; Fromont, Christophe; Hubbard, Roderick E.; Massey, Andrew; Surgenor, Allan; Wright, Lisa
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 325 - 328
反应条件
1: cyanuric fluoride; pyridine / CH2Cl2 / 1.5 h / 20 °C
2: K2CO3; DMAP / dimethylformamide / 2 h / 120 °C
3: 1.4 g / i-BuOH; NaOMe / methanol / 4.5 h / 105 °C
View Scheme
参考文献
He, Huazhong; Zatorska, Danuta; Kim, Joungnam; Aguirre, Julia; Llauger, Laura; She, Yuhong; Wu, Nian; Immormino, Robert M.; Gewirth, Daniel T.; Chiosis, Gabriela
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 381 - 390
反应条件
1: K2CO3; DMAP / dimethylformamide / 2 h / 120 °C
2: 1.4 g / i-BuOH; NaOMe / methanol / 4.5 h / 105 °C
View Scheme
参考文献
He, Huazhong; Zatorska, Danuta; Kim, Joungnam; Aguirre, Julia; Llauger, Laura; She, Yuhong; Wu, Nian; Immormino, Robert M.; Gewirth, Daniel T.; Chiosis, Gabriela
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 381 - 390
