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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
873443-68-6
合成路线
（共 6 条）
873443-68-6
→
反应条件
342417-06-5
反应条件
1: hydrogen; triethylamine; 20 palladium(II) hydroxide on carbon / methanol / 21 h / 25 °C / 2135.88 - 2482.38 Torr 2: sulfuric acid / toluene / 12 h / 70 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
110-91-8
吗啉
+
873443-66-4
→
反应条件
873443-68-6
反应条件
in methanol T=18 - 25°C; 18.75 h;
参考文献
Roche Colorado Corporation; Boundless Corporation
Patent: US2006/14959 A1, 2006 ;
Location in patent: Page/Page column 12 ;
US 20060014959 A1
529-20-4
2-甲基苯甲醛
→
反应条件
873443-68-6
反应条件
1: morpholine / isopropyl alcohol / 1 h / 20 - 33 °C 2: triethylamine / methanol / 66.02 h / 25 °C / |Reflux 3: trichlorophosphate / 10 h / 135 °C 4: methanol / 18.75 h / 18 - 25 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
70625-63-7
→
反应条件
873443-68-6
反应条件
1: triethylamine / methanol / 66.02 h / 25 °C / |Reflux 2: trichlorophosphate / 10 h / 135 °C 3: methanol / 18.75 h / 18 - 25 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
110-91-8
吗啉
+
873443-66-4
→
反应条件
873443-68-6
反应条件
in methanol T=18 - 25°C; 18.75 h; SolventTemperature; Overall yield = 182.04 g; regioselective reaction;
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
873443-68-6
→
反应条件
290296-68-3
2-[3,5-二(三氟甲基)苯基]-N,2-二甲基-N-[4-(2-甲基苯基)-6-吗啉-4-基-吡啶-3-基]丙酰胺
反应条件
1: sulfuric acid / toluene / 120 h / 70 °C 2: hydrogen; triethylamine; 20 palladium(II) hydroxide on carbon / methanol / 21 h / 25 °C / 1613.54 - 2078.99 Torr 3: N-bromosuccinmide / dichloromethane / -5 °C 4: lithium aluminium tetrahydride / tetrahydrofuran 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
