3-氟-4-(4-乙基哌嗪-1-基)苯胺合成路线 （共 3 条）
反应条件
hydrogen; nickel in methanol
T=20°C; 17 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/71752 A2, 2007 ;
Location in patent: Page/Page column 86 ;
WO 2007/071752 A2
反应条件
1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C
2: hydrogen; palladium 10 on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr
View Scheme
参考文献
Patel, Kavitkumar N.; Telvekar, Vikas N.
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 43 - 56
反应条件
1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C
2: hydrogen; palladium 10 on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr
View Scheme
参考文献
Patel, Kavitkumar N.; Telvekar, Vikas N.
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 43 - 56
