N-(3,5-二甲基苯基)-N-[(1S,2S,3R,4R)-3-羟基-4,7,7-三甲基双环[2.2.1]庚-2-基]苯磺酰胺合成路线 （共 19 条）
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
参考文献
Riehs; Urban
Monatshefte fur Chemie, 1997 , vol. 128, # 3 p. 281 - 289
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
反应条件
1: 1.) 0.25 M lithium 2-thienylcyanocuprate, 2-bromo-5-tert-butyldiphenylsilyloxy-1-pentene / 1.) THF, -78 deg C, 2 h; -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h
2: 89 percent / Ti(OEt)4 / 96 h / Heating
View Scheme
参考文献
Urban, Ernst; Knuehl, Guido; Helmchen, Guenter
Tetrahedron, 1995 , vol. 51, # 47 p. 13031 - 13038
反应条件
1: Zn, KOH / ethanol / 25 °C
2: 2.) Ca(BH4)2 / 1.) pyridine-CHCl3, 25 grad C 2.) EtOH-H2O
View Scheme
参考文献
Helmchen, Guenter; Selim, Adel; Dorsch, Dieter; Taufer, Irmtraud
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3213 - 3216
反应条件
1.1: t-BuLi / diethyl ether; pentane / 2 h / -78 °C
1.2: lithium 2-thienyl-cyanocuprate / diethyl ether; pentane; tetrahydrofuran / 1 h / -78 °C
1.3: 82 percent / diethyl ether; pentane; tetrahydrofuran / 2 h / -78 °C
2.1: 99 percent / Et3N / methanol / 15 h / 115 °C / 2850.23 Torr
View Scheme
参考文献
Krenn, Maria; Urban, Ernst
Monatshefte fur Chemie, 2002 , vol. 133, # 2 p. 127 - 137
反应条件
calcium tetrahydridoborate
1.) pyridine-CHCl3, 25 grad C 2.) EtOH-H2O; Yield given. Multistep reaction;
参考文献
Helmchen, Guenter; Selim, Adel; Dorsch, Dieter; Taufer, Irmtraud
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3213 - 3216
