Omecamtiv mecarbil合成路线 （共 8 条）
反应条件
in acetone T=20°C; Heating/reflux;
参考文献
CYTOKINETICS, INC.
Patent: WO2007/78839 A2, 2007 ;
Location in patent: Page/Page column 48 ;
反应条件
in acetone T=20°C; 5.65 h; Heating / reflux;
参考文献
Morgan, Bradley Paul; Muci, Alex; Lu, Pu-Ping; Kraynack, Erica Anne; Tochimoto, Todd; Morgans, David J.
Patent: US2006/14761 A1, 2006 ;
Location in patent: Page/Page column 33-34 ;
反应条件
in toluene T=80°C; 15 h; Inert atmosphere;
参考文献
Vinogradova, Ekaterina V.; Fors, Brett P.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 27 p. 11132 - 11135
反应条件
1: t-Bu Brett Phos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 2 h / 85 °C / Inert atmosphere 2: hydrogenchloride; palladium on carbon; hydrogen / methanol; water / 20 h / 20 °C / 760.05 Torr 3: t-Bu Brett Phos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / Inert atmosphere; Heating View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3262 - 3265
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.25 h / 20 °C / Inert atmosphere 2: t-Bu Brett Phos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / Inert atmosphere; Heating View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3262 - 3265
反应条件
t-Bu Brett Phos; palladium diacetate; caesium carbonate in tetrahydrofuran; water Inert atmosphereHeating;
参考文献
Breitler, Simon; Oldenhuis, Nathan J.; Fors, Brett P.; Buchwald, Stephen L.
Organic Letters, 2011 , vol. 13, # 12 p. 3262 - 3265
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; triethylamine / toluene / 16 h / 120 °C / Inert atmosphere 3: toluene / 15 h / 80 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 27 p. 11132 - 11135
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; triethylamine / toluene / 16 h / 120 °C / Inert atmosphere 2: toluene / 15 h / 80 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 27 p. 11132 - 11135
