反应条件
1: 5-bromo-1,3-dihydro-2H-indol-2-one With lithium hexamethyldisilazane in ethylene glycol dimethyl ether
T=-78 - -30°C;
2: N-(2,2'-bischloro)diethyl-N-(1,1-dimethylethoxy)carbonyl amine in ethylene glycol dimethyl ether
T=-30 - 20°C;
参考文献
Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; Demartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 2945 - 2959