4-(3-氟苯基)-1H-吡咯-3-甲腈合成路线 （共 2 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil
T=20 - 25°C; 1 h;
参考文献
SANOFI; COTE-DES-COMBES, Sylvain; FROISSANT, Jacques; GIBERT, Jean-Francois; MARGUET, Frank; PACAUD, Christophe; PUECH, Frederic; RAVET, Antoine
Patent: US2013/90340 A1, 2013 ;
Location in patent: Paragraph 0441-0444 ;
反应条件
1: anhydrous cyanoacetic acid; 3-fluorobenzenecarboxaldehyde With pyridine in toluene
22 h; Reflux;
2: 4-toluene-sulfonylmethyl isocyanide With sodium hydride in tetrahydrofuran; mineral oil
T=20 - 25°C; 1 h;
参考文献
SANOFI; COTE-DES-COMBES, Sylvain; FROISSANT, Jacques; GIBERT, Jean-Francois; MARGUET, Frank; PACAUD, Christophe; PUECH, Frederic; RAVET, Antoine
Patent: WO2011/161537 A2, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/161537 A2
