3-Boc-9-氧代-3-氮杂螺[5.5]十一烷合成路线 （共 5 条）
反应条件
hydrogen; palladium-on-charcoal in methanol
T=25°C; 16 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Gruenenthal GmbH
Patent: US2010/249095 A1, 2010 ;
Location in patent: Page/Page column 127 ;
US 20100249095 A1
反应条件
palladium on activated charcoal; hydrogen; triethylamine in methanol
5 h;
参考文献
Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn
Patent: US2013/324547 A1, 2013 ;
Location in patent: Paragraph 0500 ;
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
GRUENENTHAL GmbH
Patent: US2010/113417 A1, 2010 ;
Location in patent: Page/Page column 38 ;
反应条件
1: toluene-4-sulfonic acid / benzene / 70 °C / |Dean-Stark
2: hydrogen; triethylamine; palladium on activated charcoal / methanol / 5 h
View Scheme
参考文献
Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn
Patent: US2013/324547 A1, 2013 ;
反应条件
1: With sodium tetrahydroborate; cerium(III) chloride in methanol
T=-78 - -20°C; 0.5 h;
2: With water in methanol
参考文献
NEUROSEARCH A/S
Patent: WO2007/465 A1, 2007 ;
Location in patent: Page/Page column 14 ;
