1-(3-硝基-2-吡啶基)哌嗪合成路线 （共 7 条）
反应条件
in acetonitrile Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2008/112440 A1, 2008 ;
Location in patent: Page/Page column 38 ;
WO 2008/112440 A1
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 16 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 11 p. 1406 - 1411
反应条件
1: Et3N / CH2Cl2 2: H2 / 10 percent Pd/C / methanol 3: NaCNBH3 / methanol 4: CF3COOH / CH2Cl2 View Scheme
参考文献
Pinna; Loriga; Murineddu; Grella; Mura; Vargiu; Murgioni; La Colla
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 11 p. 1406 - 1411
反应条件
1: Et3N / CH2Cl2 2: H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Jacobsen, E. Jon; McCall, John M.; Ayer, Donald E.; VanDoornik, Fred J.; Palmer, John R.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1145 - 1151
反应条件
1: Et3N / CH2Cl2 2: H2 / 10 percent Pd/C / methanol 3: NaCNBH3 / methanol View Scheme
参考文献
Pinna; Loriga; Murineddu; Grella; Mura; Vargiu; Murgioni; La Colla
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 11 p. 1406 - 1411
反应条件
in tetrahydrofuran T=20°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/112440 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/112440 A1
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol
P=2378.9 Torr; 16 h;
参考文献
The Upjohn Company
Patent: US35053 E1, 1995 ;
