1-(6-氯吡啶-2-基)哌嗪合成路线 （共 6 条）
反应条件
in water; acetonitrile
参考文献
Bristol-Myers Squibb Company
Patent: US4954502 A1, 1990 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
potassium carbonate in acetonitrile 20 h; Heating;
参考文献
Ge, Hai-Xia; Wang, Li-Chen; Jiang, Zhen-Zhou; Ni, Sheng-Liang
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 10 p. 673 - 677
参考文献
US4487773 A1, ;
US 4487773 A
反应条件
1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / 20 °C 1.2: 95 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 2.1: 49 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: 94 percent / triethylamine / dimethylformamide / 6 h / 20 °C 2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / 20 °C 2.2: 95 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 3.1: 49 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 20 p. 4761 - 4768
