4-(2-噻吩基)丁-3-烯-2-酮合成路线 （共 16 条）
反应条件
morpholine*TFA T=75°C; Aldol condensation; Sealed vial; optical yield given as percent dediastereoselective reaction;
参考文献
Zumbansen, Kristina; Doehring, Arno; List, Benjamin
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 7 p. 1135 - 1136
反应条件
in ethanol; water; acetone
参考文献
Rohm and Haas Company
Patent: US6063956 A1, 2000 ;
反应条件
n-ethyl morpholine; palladium diacetate in xylene T=130°C; 6 h;
参考文献
Kasahara, Akira; Izumi, Taeko; Ogihara, Takao
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 597 - 599
反应条件
pyrrolidine in water T=20°C; 0.0833333 h;
参考文献
Tetrahedron, , vol. 61, # 21 p. 5019 - 5025
反应条件
in tetrahydrofuran T=0°C;
参考文献
Rodriques, Karen E.
Tetrahedron Letters, 1991 , vol. 32, # 10 p. 1275 - 1278
反应条件
tri-n-butyl-antimony 1 h; Ambient temperature;
参考文献
Huang, Yao-Zeng; Chen, Chen; Shen, Yanchang
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 501 - 510
反应条件
in toluene 5 h; Heating;
参考文献
Gregory, Barrie; Hinz, Werner; Jones, R. Alan; Arques, Jose Sepulveda
Journal of Chemical Research, Miniprint, 1984 , # 10 p. 2801 - 2821
反应条件
1: With sodium in methanol T=80°C; 4 h; 2: With sodium hydroxide in methanol; water T=80°C; 0.666667 h; 3: With hydrogenchloride in methanol; water Reflux;
参考文献
UNIVERSITY OF ROCHESTER; SOUTHERN RESEARCH INSTITUTE; GOLDFARB, David, S.; MADDRY, Joseph, A.; RASMUSSEN, Lynn; WHITE, Ellie, Lucile; WENNERBERG, Krister
Patent: WO2011/62964 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
sodium hydroxide in methanol
Condensation;
参考文献
Bhaskar Reddy; Somasekhar Reddy; Subba Reddy
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 12 p. 1342 - 1348
反应条件
PHT in tetrahydrofuran
T=20°C; 24 h;
参考文献
Babu, K. Suresh; Li, Xing-Cong; Jacob, Melissa R.; Zhang, Qifeng; Khan, Shabana I.; Ferreira, Daneel; Clark, Alice M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7877 - 7886
