4-(2-噻吩基)丁-3-烯-2-酮合成路线 （共 16 条）
反应条件
1: 59 percent / pyrrolidone hydrotribromide / tetrahydrofuran / 24 h / 20 °C
2: 56 percent / tetrahydrofuran / Heating
3: 93 percent / aq. NaOH / methanol / 20 °C
View Scheme
参考文献
Babu, K. Suresh; Li, Xing-Cong; Jacob, Melissa R.; Zhang, Qifeng; Khan, Shabana I.; Ferreira, Daneel; Clark, Alice M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7877 - 7886
反应条件
sulfuric acid; potassium nitrate
T=-5°C; 2 h;
参考文献
Kulikova, D. A.; Churkin, Yu. D.; Panfilova L. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 4 p. 227 - 229
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 4 p. 36 - 39
反应条件
nitric acid in acetic anhydride
T=-5°C; 2 h; var. solvents, var. temperatures, var. nitration agents; Product distribution;
参考文献
Churkin, Yu. D.; Panfilova, L. V.; Shashkov, A. S.; Burshtein, K. Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 3 p. 232 - 235
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , vol. 17, # 3 p. 325 - 328
反应条件
sodium nitrate; sulfuric acid; nitric acid
T=-15°C; 2 h; var. molar ration of HNO3; other group I and III metal nitrates; Product distribution;
参考文献
Churkin, Yu. D.; Panfilova, L. D.; Shashkov, A. S.; Burshtein, K. Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 6 p. 549 - 552
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , # 6 p. 753 - 757
反应条件
sodium hydrogen selenide in ethanol
T=50°C; 3 h;
参考文献
Nishiyama, Yutaka; Yoshida, Masanori; Ohkawa, Shigeo; Hamanaka, Sawako
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6720 - 6722
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2]; sodium formate; N-(2-amino-ethyl)-4-methyl-benzenesulphonamide in water
T=60°C; 30 h; Inert atmosphere; chemoselective reaction;
参考文献
Li, Xuefeng; Li, Liangchun; Tang, Yuanfu; Zhong, Ling; Cun, Linfeng; Zhu, Jin; Liao, Jian; Deng, Jingen
Journal of Organic Chemistry, 2010 , vol. 75, # 9 p. 2981 - 2988
