反应条件
1.1: 99 percent / hydroxyamine hydrochloride; sodium bicarbonate / methanol / 5 h / Heating
2.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate / dimethylformamide / 0.5 h / 20 °C
2.2: 16.5 g / dimethylformamide / 2 h / 140 °C
3.1: 11.9 g / oxalyl chloride; DMSO; N,N-diisopropylethylamine / CH2Cl2 / 1 h / -78 - 20 °C
View Scheme
参考文献
Li, Zhen; Chen, Weirong; Hale, Jeffrey J.; Lynch, Christopher L.; Mills, Sander G.; Hajdu, Richard; Keohane, Carol Ann; Rosenbach, Mark J.; Milligan, James A.; Shei, Gan-Ju; Chrebet, Gary; Parent, Stephen A.; Bergstrom, James; Card, Deborah; Forrest, Michael; Quackenbush, Elizabeth J.; Wickham, L. Alexandra; Vargas, Hugo; Evans, Rose M.; Rosen, Hugh; Mandala, Suzanne
Journal of Medicinal Chemistry, 2005 , vol. 48, # 20 p. 6169 - 6173
