(1R,2S,3R)-(+)-3-[N-(苯磺酰)-N-(3,5-二甲基-苯基)氨基]-2-菠烷醇合成路线 （共 17 条）
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
反应条件
1.1: Li / diethyl ether / 5 h / 0 - 20 °C
1.2: CuI / diethyl ether; toluene / 0.33 h / -10 °C
1.3: 79 percent / BF3*OEt2 / diethyl ether; toluene / 7 h / -78 - -20 °C
2.1: 93 percent / KOH; H2O / methanol
View Scheme
参考文献
Fletcher, Matthew D.; Harding, John R.; Hughes, Rachael A.; Kelly, Nicholas M.; Schmalz, Holger; Sutherland, Andrew; Willis, Christine L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 1 p. 43 - 52
反应条件
T=125°C; 64 h; autoclave;
参考文献
Urban, Ernst; Riehs, Gerhard; Knuehl, Guido
Tetrahedron Letters, 1995 , vol. 36, # 27 p. 4773 - 4776
反应条件
2: 1.) BuLi / 1.) THF, -110 deg C, 2.) -85 deg C
3: 96 percent / 2 N KOH / methanol / Ambient temperature
View Scheme
参考文献
Helmchen, Guenter; Wegner, Guenter
Tetrahedron Letters, 1985 , vol. 26, # 49 p. 6047 - 6050
反应条件
calcium tetrahydridoborate
1.) EtOH-H2O 2.) pyridine-CHCl3, 25 grad C; Yield given. Multistep reaction;
参考文献
Helmchen, Guenter; Selim, Adel; Dorsch, Dieter; Taufer, Irmtraud
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3213 - 3216
