2-溴-1-(3,4-二氯苯基)丙-1-酮合成路线 （共 3 条）
反应条件
1: With bromine in methanol
T=20°C; 0.166667 h;
2: With hydrogen bromide in methanol; water
110 h; Inert atmosphere;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; BLOUGH, Bruce; ABRAHAM, Philip
Patent: WO2010/121022 A1, 2010 ;
Location in patent: Page/Page column 70 ;
WO 2010/121022 A1
反应条件
aluminium trichloride in various solvent(s)
T=50°C; 3 h;
参考文献
Anderson; Jones
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1559 - 1565
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.17 h / 20 °C
1.2: 1 h / 0 °C
2.1: copper(ll) bromide / chloroform; ethyl acetate / 4 h / Reflux
View Scheme
参考文献
Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 123 - 136
