2-去(乙酰基硫代甲基)-2-亚甲基消旋卡多曲合成路线 （共 5 条）
反应条件
1: α-benzyl-acrylic acid With chloroformic acid ethyl ester; triethylamine in dichloromethane
T=-5°C; 0.5 h;
2: glycine benzyl ester p-toluenesulfonic acid salt With triethylamine in dichloromethane
T=-5 - 25°C; 2 h;
3: With sodium hydrogencarbonate in dichloromethane; water
Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; PRAKASH, Tarnikanti
Patent: WO2012/117410 A1, 2012 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1.1: KOH / aq. methanol
2.1: p-formaldehyde; diethylamine / ethyl acetate
2.2: aq. KOH
3.1: ethyl chloroformate; TEA / CH2Cl2
View Scheme
参考文献
Mallikarjun Reddy; Moses Babu; Sudhakar; Sharma; Sudershan Reddy; Vyas
Pharmazie, 2006 , vol. 61, # 12 p. 994 - 998
反应条件
1.1: p-formaldehyde; diethylamine / ethyl acetate
1.2: aq. KOH
2.1: ethyl chloroformate; TEA / CH2Cl2
View Scheme
参考文献
Mallikarjun Reddy; Moses Babu; Sudhakar; Sharma; Sudershan Reddy; Vyas
Pharmazie, 2006 , vol. 61, # 12 p. 994 - 998
反应条件
1: p-TsOH / toluene
2: ethyl chloroformate; TEA / CH2Cl2
View Scheme
参考文献
Mallikarjun Reddy; Moses Babu; Sudhakar; Sharma; Sudershan Reddy; Vyas
Pharmazie, 2006 , vol. 61, # 12 p. 994 - 998
反应条件
TEA; chloroformic acid ethyl ester in dichloromethane
参考文献
Mallikarjun Reddy; Moses Babu; Sudhakar; Sharma; Sudershan Reddy; Vyas
Pharmazie, 2006 , vol. 61, # 12 p. 994 - 998
