(4-硼酸基-3-氟苯基)氨基甲酸苄酯合成路线 （共 2 条）
反应条件
potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane; water T=70°C; 1 h; Inert atmosphere;
参考文献
TRIUS THERAPEUTICS; COSTELLO, Carrie, A.; SIMSON, Jaqueline, A.; DUGUID, Robert, J.; PHILLIPSON, Douglas
Patent: WO2010/42887 A2, 2010 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran
T=-72 - -65°C; 2 h;
2: With ammonium chloride in water
T=-65 - -1°C; 2 h;
参考文献
TRIUS THERAPEUTICS; COSTELLO, Carrie, A.; SIMSON, Jaqueline, A.; DUGUID, Robert, J.; PHILLIPSON, Douglas
Patent: WO2010/42887 A2, 2010 ;
Location in patent: Page/Page column 17-18 ;
