1: With [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium tert-butylate; 2-amino-2-methyl-propan-1-ol in isopropyl alcohol T=50°C; 2 h; Molecular sieve; 2: With hydrogenchloride in methanol optical yield given as percent eediastereoselective reaction;

1: {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; potassium tert-butylate; 2-amino-2-methyl-propan-1-ol; isopropyl alcohol / 2 h / 50 °C / Inert atmosphere; Molecular sieve 2: hydrogenchloride / methanol / 20 °C 3: sodium hydroxide / dichloromethane; water / 3 h / 0 - 20 °C View Scheme