1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 24 h / 20 °C / 2 1.2: 65 percent / diisopropylethylamine / tetrahydrofuran / 6 h / Heating 2.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C 2.2: 75 percent / HMPA; acetic acid / tetrahydrofuran 3.1: H2 / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 3750.3 Torr View Scheme

1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 24 h / 20 °C / 2 1.2: 65 percent / diisopropylethylamine / tetrahydrofuran / 6 h / Heating 2.1: 99 percent / H2 / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 3750.3 Torr View Scheme

1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 24 h / 20 °C / 2 1.2: 65 percent / diisopropylethylamine / tetrahydrofuran / 6 h / Heating 2.1: 81 percent / potassium bis(trimethylsilyl)amide; HMPA / tetrahydrofuran / 2 h / -78 - -70 °C 3.1: H2 / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 3750.3 Torr View Scheme