1-环己基-1,2,3,4-四氢异喹啉合成路线 （共 16 条）
反应条件
C25H28ClIrN2O3; hydrogen in 2,2,2-trifluoroethanol
T=75°C; P=15001.5 Torr; 2 h; Autoclave; chemoselective reaction;
参考文献
Villa-Marcos, Barbara; Tang, Weijun; Wu, Xiaofeng; Xiao, Jianliang
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6934 - 6939
反应条件
sodium hydroxide in ethanol; water
3 h; Heating;
参考文献
Saitoh, Toshiaki; Abe, Kenji; Ishikawa, Masami; Nakatani, Masanao; Shimazu, Seiichiro; Satoh, Noriyuki; Yoneda, Fumio; Taguchi, Kyoji; Horiguchi, Yoshie
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 2 p. 241 - 252
反应条件
hydrogenchloride in methanol
49 h; Heating;
参考文献
Seebach, Dieter; Lohmann, Jean-Jacques; Syfrig, Max A.; Yoshifuji, Masaaki
Tetrahedron, 1983 , vol. 39, # 12 p. 1963 - 1974
反应条件
1: P2O5; POCl3 / xylene / 2.5 h / Heating
2: NaBH4 / ethanol / 60 h / 20 °C
View Scheme
参考文献
Naito, Ryo; Yonetoku, Yasuhiro; Okamoto, Yoshinori; Toyoshima, Akira; Ikeda, Ken; Takeuchi, Makoto
Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6597 - 6606
反应条件
1: 97 percent / 10percent aq. NaOH / CH2Cl2 / 0.25 h
2: polyphosphoric acid / 4 h / 140 °C
3: NaBH4 / ethanol / 16 h / Heating
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: 97 percent / 10percent aq. NaOH / CH2Cl2 / 0.25 h
2: polyphosphoric acid / 4 h / 140 °C
3: NaBH4 / ethanol / 16 h / Heating
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: 91 percent / Et3N / diethyl ether / 6 h / Heating
2: 1) n-BuLi / 1) THF, -78 deg C, 1 h; 2) -78 deg C, 2 h, then room t.
3: 66 percent / 2.06 M HCl / methanol / 49 h / Heating
View Scheme
参考文献
Seebach, Dieter; Lohmann, Jean-Jacques; Syfrig, Max A.; Yoshifuji, Masaaki
Tetrahedron, 1983 , vol. 39, # 12 p. 1963 - 1974
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 1 h; 2) -78 deg C, 2 h, then room t.
2: 66 percent / 2.06 M HCl / methanol / 49 h / Heating
View Scheme
参考文献
Seebach, Dieter; Lohmann, Jean-Jacques; Syfrig, Max A.; Yoshifuji, Masaaki
Tetrahedron, 1983 , vol. 39, # 12 p. 1963 - 1974
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 1 h; 2) -78 deg C, 2 h, then room t.
2: 66 percent / 2.06 M HCl / methanol / 49 h / Heating
View Scheme
参考文献
Seebach, Dieter; Lohmann, Jean-Jacques; Syfrig, Max A.; Yoshifuji, Masaaki
Tetrahedron, 1983 , vol. 39, # 12 p. 1963 - 1974
反应条件
1: NaAlH2(OCH2CH2OCH3)2 / tetrahydrofuran / 7 h / 0 - 5 °C / further solvent, varying concentration, temperature and reaction time
2: 91 percent / Et3N / diethyl ether / 6 h / Heating
3: 1) n-BuLi / 1) THF, -78 deg C, 1 h; 2) -78 deg C, 2 h, then room t.
4: 66 percent / 2.06 M HCl / methanol / 49 h / Heating
View Scheme
参考文献
Seebach, Dieter; Lohmann, Jean-Jacques; Syfrig, Max A.; Yoshifuji, Masaaki
Tetrahedron, 1983 , vol. 39, # 12 p. 1963 - 1974
