5-(羟基甲基)吡嗪-2-氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol
T=20°C; 12 h;
参考文献
Shimamura, Tadashi; Shibata, Jun; Kurihara, Hideki; Mita, Takashi; Otsuki, Sachie; Sagara, Takeshi; Hirai, Hiroshi; Iwasawa, Yoshikazu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3751 - 3754
反应条件
1: 88 percent / DPPA; Et3N / dioxane / 3 h / 100 °C
2: NBS; AIBN / CCl4 / 12 h / 100 °C
3: 18-crown-6-ether / acetonitrile / 1 h / 20 °C
4: aq. NaOH / methanol / 12 h / 20 °C
View Scheme
参考文献
Shimamura, Tadashi; Shibata, Jun; Kurihara, Hideki; Mita, Takashi; Otsuki, Sachie; Sagara, Takeshi; Hirai, Hiroshi; Iwasawa, Yoshikazu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3751 - 3754
反应条件
1: NBS; AIBN / CCl4 / 12 h / 100 °C
2: 18-crown-6-ether / acetonitrile / 1 h / 20 °C
3: aq. NaOH / methanol / 12 h / 20 °C
View Scheme
参考文献
Shimamura, Tadashi; Shibata, Jun; Kurihara, Hideki; Mita, Takashi; Otsuki, Sachie; Sagara, Takeshi; Hirai, Hiroshi; Iwasawa, Yoshikazu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3751 - 3754
反应条件
1: 18-crown-6-ether / acetonitrile / 1 h / 20 °C
2: aq. NaOH / methanol / 12 h / 20 °C
View Scheme
参考文献
Shimamura, Tadashi; Shibata, Jun; Kurihara, Hideki; Mita, Takashi; Otsuki, Sachie; Sagara, Takeshi; Hirai, Hiroshi; Iwasawa, Yoshikazu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3751 - 3754
