2-(2-甲氧基乙氧基)-5-硝基吡啶合成路线 （共 4 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/77414 A1, 2006 ;
Location in patent: Page/Page column 139 ;
WO 2006/077414 A1
反应条件
sodium hydride
T=20°C; 0.833333 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/53094 A1, 2007 ;
Location in patent: Page/Page column 67 ;
WO 2007/053094 A1
参考文献
Friedman et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 1204
反应条件
1: trichlorophosphate; phosphorus pentachloride / 16 h / 60 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 23 °C
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参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard
Patent: WO2013/13815 A1, 2013 ;
WO 2013/013815 A1
