N,N-二异丙基-3-苯基-2-丙烯胺合成路线 （共 8 条）
反应条件
sulfuric acid; acetic acid in n-heptane T=80 - 85°C;
参考文献
Ragactives, S.L.U.
Patent: EP2281801 A1, 2011 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1.1: methanesulfonic acid / 3 h / 100 °C 2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2.2: 0.08 h 2.3: pH 8 View Scheme
参考文献
LEK Pharmaceuticals d.d.
Patent: EP2364966 A1, 2011 ;
反应条件
1.1: methanesulfonic acid / 3 h / 100 °C 2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2.2: 0.08 h 2.3: pH 8 3.1: 1,1-dimethylpropan-1-ol / 25 - 70 °C 4.1: potassium carbonate / toluene; water / 1 h / 50 °C View Scheme
参考文献
LEK Pharmaceuticals d.d.
Patent: EP2364966 A1, 2011 ;
反应条件
1.1: methanesulfonic acid / 3 h / 100 °C 2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2.2: 0.08 h 2.3: pH 8 3.1: 1,1-dimethylpropan-1-ol / 25 - 70 °C 4.1: potassium carbonate / toluene; water / 1 h / 50 °C 5.1: triethylamine / dichloromethane / 0 - 25 °C View Scheme
反应条件
potassium carbonate; potassium iodide in methanol; toluene
20 h; Reflux;
参考文献
LEK Pharmaceuticals d.d.
Patent: EP2364966 A1, 2011 ;
Location in patent: Page/Page column 17-18 ;
反应条件
palladium diacetate; benzoic acid in toluene
T=110°C; 8 h;
参考文献
Wagh, Yogesh S.; Tambade, Pawan J.; Sawant, Dinesh N.; Bhanage, Bhalchandra M.
European Journal of Organic Chemistry, 2010 , # 26 p. 5071 - 5076
反应条件
phosphoric acid in acetic acid
T=115°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Cohen, Theodore; Onopchenko, Anatoli
Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4531 - 4537
反应条件
phosphoric acid in acetic acid
5 h; Heating; Further byproducts given;
参考文献
Manninen, Kalle; Karjalainen, Aira
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 3 p. 190 - 195
