1-苄基-5-硝基-1H-咪唑-4-甲醛合成路线 （共 8 条）
反应条件
sodium chlorite; aminosulfonic acid in methanol; water T=20°C; 1.5 h;
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
formic acid
T=115°C; 18 h;
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 75 °C
2: 72 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 0.17 h / -78 °C
3: formic acid / 18 h / 115 °C
View Scheme
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
1: 72 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 0.17 h / -78 °C
2: formic acid / 18 h / 115 °C
View Scheme
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
dichloro-acetic acid; oxalic acid; dicyclohexyl-carbodiimide
1) dimethyl sulfoxide, 3 h, room temp.; 2) methanol; Yield given. Multistep reaction;
参考文献
Baker; Putt; Hollis Showalter
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 629 - 634
反应条件
1: 1) O3; 2) NaBH4 / 1) -78 deg C, CH2Cl2, methanol; 2) 95percent ethanol, -40 deg C, 1 h
2: 1) N,N'-dicyclohexylcarbodiimide, dichloroacetic acid; 2) oxalic acid / 1) dimethyl sulfoxide, 3 h, room temp.; 2) methanol
View Scheme
参考文献
Baker; Putt; Hollis Showalter
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 629 - 634
反应条件
1.1: NaClO2; NH2SO3H / methanol; H2O / 1.5 h / 20 °C
2.1: CDI / tetrahydrofuran / 1 h / Heating
2.2: 68 percent / t-BuOK / 0 - 5 °C
3.1: 95 percent / Fe; HCl / ethanol / 20 h / Heating
View Scheme
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
1.1: NaClO2; NH2SO3H / methanol; H2O / 1.5 h / 20 °C
2.1: CDI / tetrahydrofuran / 1 h / Heating
2.2: 68 percent / t-BuOK / 0 - 5 °C
View Scheme
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
