potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; water; benzene Suzuki coupling; 12 h; Heating;

1.1: n-butyllithium / tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere 2.1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere 3.1: bromine / hexane / -78 - 20 °C / Inert atmosphere 3.2: 40 °C / Inert atmosphere 4.1: bis-triphenylphosphine-palladium(II) chloride; formic acid; tributyl-amine / N,N-dimethyl-formamide / 12.08 h / 20 - 60 °C / Inert atmosphere View Scheme