4-氟苄基 4-(甲硫基)苯基甲酮合成路线 （共 4 条）
反应条件
aluminium trichloride in dichloromethane
T=20°C; Friedel-Crafts reaction; 2.5 h;
参考文献
Caturla, Francisco; Jimenez, Juan-Miguel; Godessart, Nuria; Amat, Merce; Cardenas, Alvaro; Soca, Lidia; Beleta, Jordi; Ryder, Hamish; Crespo, Maria I.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3874 - 3886
反应条件
1: 4-bromomethyl-fluorobenzene With magnesium in diethyl ether
2 h; Heating;
2: 4-cyanophenyl methyl sulfide in diethyl ether
T=20°C; 14 h;
参考文献
ABBOTT LABORATORIES
Patent: EP1206474 B1, 2004 ;
Location in patent: Page 11; 12 ;
参考文献
Penning, Thomas D.; Kramer, Steven W.; Lee, Len F.; Collins, Paul W.; Koboldt, Carol M.; Seibert, Karen; Veenhuizen, Amy W.; Zhang, Yan Y.; Isakson, Peter C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2121 - 2124
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
G. D. Searle and Co.
Patent: US5486534 A1, 1996 ;
