1-苄基-3,5-二氯吡嗪-2(1h)-酮合成路线 （共 5 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C;
参考文献
De Borggraeve, Wim M.; Rombouts, Frederik J.R.; Van der Eycken, Erik V.; Toppet, Suzanne M.; Hoornaert, Georges J
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5693 - 5695
反应条件
1: T=0 - 55°C; 18 h;
2: With potassium dihydrogenphosphate in dichloromethane; water
0.5 h;
参考文献
Harker, Wesley R.R.; Delaney, Patrick M.; Simms, Michael; Tozer, Matthew J.; Harrity, Joseph P.A.
Tetrahedron, 2013 , vol. 69, # 5 p. 1546 - 1552
反应条件
in 1,2-dichloro-benzene
T=90°C; Cooling;
参考文献
BAYER SCHERING PHARMA ATIENGESELLSCHAFT
Patent: US2010/298293 A1, 2010 ;
Location in patent: Page/Page column 46 ;
US 20100298293 A1
反应条件
1: triethylammonium chloride / chlorobenzene
View Scheme
参考文献
De Borggraeve, Wim M.; Verbist, Bie M.P.; Rombouts, Frederik J.R.; Pawar, Vijaykumar G.; Smets, Wim J.; Kamoune, Laila; Alen, Jo; Van Der Eycken, Erik V.; Compernolle, Frans; Hoornaert, Georges J.
Tetrahedron, 2004 , vol. 60, # 50 p. 11597 - 11612
反应条件
sodium hydride in tetrahydrofuran
Heating;
参考文献
De Borggraeve, Wim M.; Rombouts, Frederik J.R.; Verbist, Bie M.P.; Van Der Eycken, Erik V.; Hoornaert, Georges J.
Tetrahedron Letters, 2002 , vol. 43, # 3 p. 447 - 449
