3-氰基-4-甲基-2,6-二氯吡啶合成路线 （共 27 条）
反应条件
trichlorophosphate T=200°C; 7 h;
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
sodium carbonate; trichlorophosphate in quinoline
反应条件
trichlorophosphate T=105°C; 3 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 1007 - 1010
反应条件
1: NaOH / 2 h / 140 °C 2: 1 percent / POCl3 / 3 h / 105 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 1007 - 1010
反应条件
sulfuric acid T=98°C; 6 h;
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
hydrogen; palladium on activated charcoal 1.) MeOH, from 20 deg C to 40 deg C, 30 min, 2.) MeOH, 50 psi, 3 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Pelisson, Marcelo M. M.; Da Silva, Gil Valdo Jose; Clive, Derrick L. J.; Coltart, Don M.; Hof, Fraser A.
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 653 - 658
反应条件
1: conc. H2SO4 / Heating 2: NaOH, Br2 / Heating 3: various solvent(s) View Scheme
参考文献
Proudfoot; Hargrave; Kapadia; Patel; Grozinger; McNeil; Cullen; Cardozo; Tong; Kelly; Rose; David; Mauldin; Fuchs; Vitous; Hoermann; Klunder; Raghavan; Skiles; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4830 - 4838
反应条件
sulfuric acid; water; nitric acid T=70 - 105°C; 2 h;
参考文献
Wang, Yamin; Bullock, William H.; Chen, Libing
Patent: US6677352 B1, 2004 ;
Location in patent: Page/Page column 46 ;
反应条件
5 Pd(II)/C(eggshell); ammonium formate in methanol T=20°C; 72 h;
参考文献
Kiselev, Evgeny; Agama, Keli; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1682 - 1697
反应条件
hydrogen; sodium acetate; palladium dichloride in methanol T=23°C; P=760.051 Torr; 14 h;
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
Location in patent: Paragraph 0146 ;
