3-氰基-4-甲基-2,6-二氯吡啶合成路线 （共 27 条）
反应条件
sodium acetate in methanol
参考文献
American Home Products Corporation
Patent: US4859671 A1, 1989 ;
US 4859671 A
反应条件
1: conc. H2SO4 / Heating 2: NaOH, Br2 / Heating View Scheme
参考文献
Proudfoot; Hargrave; Kapadia; Patel; Grozinger; McNeil; Cullen; Cardozo; Tong; Kelly; Rose; David; Mauldin; Fuchs; Vitous; Hoermann; Klunder; Raghavan; Skiles; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4830 - 4838
反应条件
1: hydrogen; sodium acetate; palladium dichloride / methanol / 14 h / 23 °C / 760.05 Torr 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3.5 h / Reflux View Scheme
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
反应条件
in water
T=130°C; 3 h;
参考文献
Fuji Photo Film Co., Ltd.
Patent: EP1564259 A1, 2005 ;
Location in patent: Page/Page column 79 ;
反应条件
diisobutylaluminium hydride in dichloromethane; toluene
T=-78 - 20°C; Reduction; 2 h;
参考文献
Sarkar, Tarun K.; Ghosh, Sunil K.; Chow, Tahsin J.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3111 - 3115
反应条件
triethylamine in methanol
T=45 - 50°C; 14 h;
参考文献
Skowronski, Romuald; Strzyzewski, Wieslaw
Polish Journal of Chemistry, 1991 , vol. 65, # 5-6 p. 883 - 888
反应条件
ammonia
T=20°C; 20 h;
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Smith, Terrance P.; Steel, Peter J.
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 979 - 984
反应条件
triethylamine in methanol
T=45 - 50°C; 14 h;
参考文献
Skowronski, Romuald; Strzyzewski, Wieslaw
Polish Journal of Chemistry, 1991 , vol. 65, # 5-6 p. 883 - 888
反应条件
in hexane; chloroform
参考文献
Sandoz, Inc.
Patent: US4052510 A1, 1977 ;
反应条件
ammonia
T=150°C; 16 h;
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Smith, Terrance P.; Steel, Peter J.
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 979 - 984
