D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
thionyl chloride in diethyl ether T=-10°C;
参考文献
Kearns, Jeff; Kayser, Margaret
Tetrahedron Letters, 1994 , vol. 35, # 18 p. 2845 - 2848
反应条件
sodium hydroxide in water T=0°C; 1 h;
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig, A.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; SOLL, Richard; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; SHEN, Changmao; SUN, Fei
Patent: WO2012/122716 A1, 2012 ;
Location in patent: Page/Page column 52-53 ;
参考文献
Mc Kenzie; Clough
Journal of the Chemical Society, 1909 , vol. 95, p. 780,789
反应条件
1: 82 percent / 2 M aq. NaOH / 1 h / 0 °C 2: N-methylmorpholine / 0.5 h / -5 °C 3: 51 percent / diethyl ether; tetrahydrofuran 4: 91 percent / Et3N, silver benzoate / 3 h 5: 77 percent / H2, conc. HCl / 10percent Pd/C / methanol / 3.5 h / 760 Torr / Ambient temperature 6: 74 percent / 10percent aq. NaOH / 3 h View Scheme
参考文献
Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Mat-Zin, Ab. Rasid
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2047 - 2054
反应条件
1: 91 percent / H2 / PtO2 / acetic acid / Ambient temperature 2: 82 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Hayashi, Tamio; Konishi, Mitsuo; Fukushima, Motoo; Kanehira, Koichi; Hioki, Takeshi; Kumada, Makoto
Journal of Organic Chemistry, 1983 , vol. 48, # 13 p. 2195 - 2202
反应条件
1: NaBH4; H2SO4 2: aq. NaHCO3 / 1.5 h / 20 °C 3: K2CO3 / 100 - 130 °C View Scheme
参考文献
Janey; Iwama; Kozmin; Rawal
Journal of Organic Chemistry, 2000 , vol. 65, # 26 p. 9059 - 9068
反应条件
thionyl chloride 2 h; Heating;
参考文献
Davies, Stephen G.; Sanganee, Hitesh J.; Szolcsanyi, Peter
Tetrahedron, 1999 , vol. 55, # 11 p. 3337 - 3354
反应条件
thionyl chloride 20 h; Ambient temperature;
参考文献
Nagai, Yuriko; Kusumi, Takenori
Tetrahedron Letters, 1995 , vol. 36, # 11 p. 1853 - 1856
反应条件
1: SOCl2 / 2 h / 20 °C 2: 3 h / Ambient temperature View Scheme
参考文献
Juarez, Jorge; Gnecco, Dino; Galindo, Alberto; Enriquez, Raul G.; Marazano, Christian; Reynolds, William F.
Tetrahedron Asymmetry, 1997 , vol. 8, # 2 p. 203 - 206
反应条件
1: chloroform-d1; water / 0.33 h / 20 °C 2: DCl; water-d2 / chloroform View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 3 p. 829 - 832
Angew. Chem., , vol. 126, # 3 p. 848 - 851,4
