D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
1: 60 percent / Et3N / methanol; H2O / 6 h View Scheme
参考文献
Hendrix; Roets; Bervoets; Thomas; Pijcke; Busson; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 4 p. 215 - 219
反应条件
1: 100 percent / SOCl2 / 2 h / Heating 2: 41 percent / diethyl ether / 3 h 3: 82 percent / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Sanganee, Hitesh J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 387 - 398
反应条件
thionyl chloride T=0 - 20°C; RefluxInert atmosphere;
参考文献
March, Taryn L.; Johnston, Martin R.; Duggan, Peter J.
Organic Letters, 2012 , vol. 14, # 1 p. 182 - 185
反应条件
1: SOCl2 / 2 h / 20 °C 2: 3 h / Ambient temperature View Scheme
参考文献
Juarez, Jorge; Gnecco, Dino; Galindo, Alberto; Enriquez, Raul G.; Marazano, Christian; Reynolds, William F.
Tetrahedron Asymmetry, 1997 , vol. 8, # 2 p. 203 - 206
反应条件
1: SOCl2 / 24 h / Ambient temperature 2: NaHCO3 / ethanol / 48 h / Ambient temperature 3: 1.) Mg / 1.) THF, reflux, 2.) THF, r.t., 48 h 4: 81 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Sanganee, Hitesh J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 387 - 398
反应条件
thionyl chloride 20 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 36, # 11 p. 1853 - 1856
反应条件
1: 73 percent / LiAlH4
View Scheme
参考文献
Veeresa; Datta, Apurba
Tetrahedron Letters, 1998 , vol. 39, # 19 p. 3069 - 3070
反应条件
1: SOCl2 / 20 °C
2: acetonitrile / 20 °C
View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Sanganee, Hitesh J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 387 - 398
反应条件
potassium hydride
1.) THF, overnight, 2.) THF, 3 h; Yield given. Multistep reaction;
参考文献
Smith III, Amos B.; Yager, Kraig M.; Taylor, Carol M.
Journal of the American Chemical Society, 1995 , vol. 117, # 44 p. 10879 - 10888
反应条件
1.1: LiAlH4 / tetrahydrofuran / Heating
2.1: MgSO4 / CH2Cl2 / 2 h / 20 °C
3.1: NaH / tetrahydrofuran / 2.25 h / 20 - 40 °C
3.2: 85 percent / 3N HCl / tetrahydrofuran; diethyl ether / 3 h / 20 °C
View Scheme
参考文献
Howson, Suzanne E.; Allan, Laura E. N.; Chmel, Nikola P.; Clarkson, Guy J.; Deeth, Robert J.; Faulkner, Alan D.; Simpson, Daniel H.; Scott, Peter
Dalton Transactions, 2011 , vol. 40, # 40 p. 10416 - 10433
