D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
5-(ethylthio)methyl-3-hydroxy-2-Me-4-pyridinecarbaldehyde; CHES buffer; potassium chloride; ethylenediaminetetraacetic acid in water T=20°C; Kinetics; Further Variations:Reagents;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 12 p. 3277 - 3287
反应条件
Bacillus licheniformis; sodium hydrogencarbonate; BASIONICreg; BC 01 in water; water-d2 T=30°C; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 17 p. 2491 - 2498
反应条件
1: Et3N 2: PPTS 3: 51 percent / n-BuLi; CuCN; n-BuLi / tetrahydrofuran / -78 deg C; -78 deg C to 0 deg C; -78 deg C 4: 6N HCl / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 16 p. 2817 - 2820
反应条件
1: 51 percent / n-BuLi; CuCN; n-BuLi / tetrahydrofuran / -78 deg C; -78 deg C to 0 deg C; -78 deg C 2: 6N HCl / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 16 p. 2817 - 2820
反应条件
1: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 2 h 2: 1.) 3N HCl, 2.) Dowex 50*8 / 1.) THF, room temperature, 2 h. View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1411 - 1416
反应条件
1: 1) 10percent aq.NaOH, Bu4NHSO4 / 1) CH2Cl2, r.t., 1 h, 2) CH2Cl2, r.t., 4 h 2: 93 percent / acetonitrile; H2O / Ambient temperature 3: 69 percent / 6 N HCl / Heating View Scheme
参考文献
Synthesis, , # 11 p. 989 - 993
反应条件
1: 93 percent / acetonitrile; H2O / Ambient temperature 2: 69 percent / 6 N HCl / Heating View Scheme
参考文献
Synthesis, , # 11 p. 989 - 993
反应条件
1.1: 69 percent / NH2OH*HCl; AcONa / ethanol / 12 h / Heating 2.1: NaH / dimethylformamide / 1 h / 0 °C 2.2: 91 percent / dimethylformamide / 2 h / 20 °C 3.1: (R,S)-norephedrine; BH3 / tetrahydrofuran / 48 h / 30 °C 4.1: 78 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 1 p. 91 - 105
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: 91 percent / dimethylformamide / 2 h / 20 °C 2.1: (R,S)-norephedrine; BH3 / tetrahydrofuran / 48 h / 30 °C 3.1: 78 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 1 p. 91 - 105
反应条件
1: (R,S)-norephedrine; BH3 / tetrahydrofuran / 48 h / 30 °C 2: 78 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 1 p. 91 - 105
