D-(-)-alpha-苯甘氨酸合成路线 （共 142 条）
反应条件
1.1: tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere 1.2: -20 °C / Inert atmosphere 2.1: hydrogenchloride; water / ethanol / 0.08 h / 130 °C / Inert atmosphere; Microwave irradiation 3.1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 16 h / 20 °C / 760.05 Torr 4.1: hydrogenchloride; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation 4.2: DOWEX 50W-X8 ion-exchange column View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 12 p. 1274 - 1281
反应条件
1: hydrogenchloride / water / 3 h / 20 °C 2: PLP / aq. buffer / 24 h / 40 °C / pH 8.0 / |Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 17 p. 3327 - 3332
反应条件
1.1: ammonium chloride 1.2: 24 h / 20 °C 2.1: hydrogenchloride / water / 3 h / 20 °C 3.1: PLP / aq. buffer / 24 h / 40 °C / pH 8.0 / |Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 17 p. 3327 - 3332
反应条件
(R)-lt;lt;N-n-Hexadecyl-N-(2-hydroxy-1-propyl)aminogt;methylgt;pyridine; Cu in various solvent(s) T=25°C; enantioselectivity of cleavage; other chiral ligands; Rate constant;
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4194 - 4201
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 74, # 3-4 p. 184 - 191
反应条件
potassium hydroxide; potassium dihydrogenphosphate; Alcaligenes faecalis penicillin acylase in water T=25°C; pH=7.5; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 18 p. 2901 - 2906
反应条件
potassium phosphate buffer; Pseudomonas sp. AJ-11220 in various solvent(s) T=30°C; 2 h; pH 8.0; enzymatic reaction;
参考文献
Agricultural and Biological Chemistry, , vol. 51, # 3 p. 715 - 720
反应条件
potassium phosphate buffer; Pseudomonas sp. AJ-11220 in various solvent(s) T=30°C; 2 h;
参考文献
Agricultural and Biological Chemistry, , vol. 51, # 3 p. 721 - 728
反应条件
lithium hydroxide; Amberlite IR-120 1) THF, room temperature, 2) H2O, room temperature, 15 h; Yield given. Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 75, # 6 p. 1965 - 1978
反应条件
hydrogenchloride Heating; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zheng, Nan; Armstrong III, Joseph D.; McWilliams, J. Christopher; Volante
Tetrahedron Letters, 1997 , vol. 38, # 16 p. 2817 - 2820
