5 palladium on charcoal; hydrogen in tetrahydrofuran T=40°C; P=4121.6 Torr; 20 h; Large scale;

1: triethylamine; palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / 6 h / 30 - 55 °C / |Inert atmosphere; |Large scale 2: 5 palladium on charcoal; hydrogen / tetrahydrofuran / 20 h / 40 °C / 4121.6 Torr / |Large scale View Scheme

1: toluene; water / 20 h / 40 °C 2: toluene / 15 h / 85 °C / |Large scale 3: triethylamine; palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / 6 h / 30 - 55 °C / |Inert atmosphere; |Large scale 4: 5 palladium on charcoal; hydrogen / tetrahydrofuran / 20 h / 40 °C / 4121.6 Torr / |Large scale View Scheme

1: toluene / 15 h / 85 °C / |Large scale 2: triethylamine; palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / 6 h / 30 - 55 °C / |Inert atmosphere; |Large scale 3: 5 palladium on charcoal; hydrogen / tetrahydrofuran / 20 h / 40 °C / 4121.6 Torr / |Large scale View Scheme