5-羟基-2-甲氧基苯甲酸甲酯合成路线 （共 10 条）
反应条件
potassium carbonate in methanol
T=20°C; 3 h;
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
P=2206.5 Torr; Yield given;
参考文献
Schmidt, Ulrich; Boekens, Hilmar; Lieberknecht, Albrecht; Griesser, Helmut
Liebigs Annalen der Chemie, 1983 , # 9 p. 1459 - 1467
反应条件
1.1: K2CO3 / dimethylformamide
1.2: 70 percent / dimethylformamide / 1.5 h / 35 °C
2.1: 50 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
1.1: 10 percent / pyridine / CH2Cl2 / 48 h / 20 °C
2.1: K2CO3 / dimethylformamide
2.2: 70 percent / dimethylformamide / 1.5 h / 35 °C
3.1: 50 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
1.1: 24 percent / H2SO4 / CH2Cl2 / Heating
2.1: 10 percent / pyridine / CH2Cl2 / 48 h / 20 °C
3.1: K2CO3 / dimethylformamide
3.2: 70 percent / dimethylformamide / 1.5 h / 35 °C
4.1: 50 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
trifluoroacetic acid
Heating; Further byproducts given;
参考文献
Harwood, Laurence M.
Journal of the Chemical Society, Chemical Communications, 1983 , # 9 p. 530 - 532
参考文献
Tori; Hamaguchi; Sagawa; Sono; Asakawa
Journal of Organic Chemistry, 1996 , vol. 61, # 16 p. 5362 - 5370
反应条件
TiCl4-treated silica
Diels-Alder reaction; 0.5 h; microwave irradiation; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Moreno, Andres; Gomez, Maria Victoria; Vazquez, Ester; De La Hoz, Antonio; Diaz-Ortiz, Angel; Prieto, Pilar; Mayoral, Jose Antonio; Pires, Elisabet
Synlett, 2004 , # 7 p. 1259 - 1263
反应条件
1: 80 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
2: 97 percent / H2O / 48 h / 0 - 5 °C
View Scheme
参考文献
Schmidt, Ulrich; Boekens, Hilmar; Lieberknecht, Albrecht; Griesser, Helmut
Liebigs Annalen der Chemie, 1983 , # 9 p. 1459 - 1467
反应条件
hydrogenchloride; sodium hydroxide in methanol
参考文献
Aventis Pharmaceuticals Inc.
Patent: US6194406 B1, 2001 ;
US 6194406 B1
