1: With sodium hydroxide; water in tetrahydrofuran T=20°C; 48 h; 2: With hydrogenchloride; water in tetrahydrofuran pH=~ 3;

1: piperidine-4-methanol With potassium carbonate in N,N-dimethyl-formamide; acetonitrile T=20°C; 0.166667 h; 2: 2-methylsulphonylpyrimidine-5-carboxylic acid, ethyl ester in N,N-dimethyl-formamide; acetonitrile 0.333333 h;

potassium carbonate in N,N-dimethyl-formamide T=20°C; 2.5 h;

1: bromine; acetic acid / 1.5 h / Reflux 2: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C View Scheme

1.1: ethanol; sodium / benzene / 5 h / 0 - 50 °C 1.2: 4 h 2.1: hydrogenchloride / ethanol / Reflux 3.1: bromine; acetic acid / 1.5 h / Reflux 4.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux 5.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C View Scheme

1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C View Scheme

1: hydrogenchloride / ethanol / Reflux 2: bromine; acetic acid / 1.5 h / Reflux 3: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux 4: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C View Scheme