[(1-异丙基哌啶-3-基)甲基]胺合成路线 （共 3 条）
反应条件
1: With trifluoroacetic acid in dichloromethane
T=0°C; 18 h;
2: With sodium hydroxide in dichloromethane; water
pH=~ 14;
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
Location in patent: Page/Page column 29 ;
WO 2011/117254 A1
反应条件
1.1: hydrogen / Rh/Al2O3 / methanol / 16 h / 50 °C / 30003 Torr
2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h
2.2: pH ~ 14
3.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C
3.2: pH ~ 14
View Scheme
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
WO 2011/117254 A1
反应条件
1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h
1.2: pH ~ 14
2.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C
2.2: pH ~ 14
View Scheme
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
WO 2011/117254 A1
