反应条件
1: 4-Chlorothieno[3,2-d]pyrimidine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; Inert atmosphere;
参考文献
Disch, Jeremy S.; Evindar, Ghotas; Chiu, Cynthia H.; Blum, Charles A.; Dai, Han; Jin, Lei; Schuman, Eli; Lind, Kenneth E.; Belyanskaya, Svetlana L.; Deng, Jianghe; Coppo, Frank; Aquilani, Leah; Graybill, Todd L.; Cuozzo, John W.; Lavu, Siva; Mao, Cheney; Vlasuk, George P.; Perni, Robert B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3666 - 3679