2-溴-1-(5-溴-1H-吡咯并[2,3-B]吡啶-3-基)-乙酮合成路线 （共 3 条）
反应条件
in tetrahydrofuran 6 h; Heating / reflux;
参考文献
EISAI LONDON RESEARCH LABORATORIES LIMITED
Patent: WO2008/95943 A1, 2008 ;
Location in patent: Page/Page column 195 ;
WO 2008/095943 A1
反应条件
1: With AlCl3, aluminium chloride in carbon disulfide
T=50°C; 1.16667 h;
2: With water; sodium hydrogencarbonate in tetrahydrofuran; carbon disulfide; ethyl acetate
T=0°C; pH=1 - 3;
参考文献
Eisai Co., Ltd.
Patent: US2007/72896 A1, 2007 ;
Location in patent: Page/Page column 66 ;
反应条件
1: 5-Bromo-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane
0.5 h;
2: monobromoacetic acid chloride in dichloromethane
2 h;
参考文献
SGX Pharmaceuticals, Inc.
Patent: US2006/30583 A1, 2006 ;
Location in patent: Page/Page column 105 ;
US 20060030583 A1
