1: 5-ethynyl-4-methyl-2-methylthiopyrimidine With hydroxylamine hydrochloride; N-butylamine; copper(l) chloride in tetrahydrofuran; methanol T=0°C; Metallation; 2: 3-bromopropargyl alcohol in tetrahydrofuran; methanol T=10 - 20°C; Substitution; 5 h; Further stages.;