5-溴-4,7-二氮杂吲哚合成路线 （共 7 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 15 h;
参考文献
WO2006/15124 A2, ;
Page/Page column 102-103 ;
WO 2006/015124 A2
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=80°C; 1.5 h;
参考文献
WO2012/178123 A1, ;
Page/Page column 63-64 ;
WO 2012/178123 A1
反应条件
1: pyridine / tetrahydrofuran / 96 h 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 75 °C View Scheme
参考文献
WO2011/149950 A2, ;
WO 2011/149950 A2
反应条件
iodine; potassium hydroxide in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere;
参考文献
EISAI R andamp; D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh
Patent: WO2010/15803 A1, 2010 ;
Location in patent: Page/Page column 43 ;
WO 2010/015803 A1
反应条件
1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride in N,N-dimethyl-formamide T=0 - 5°C; 0.5 h; 2: p-toluenesulfonyl chloride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
ABBOTT LABORATORIES
Patent: US2009/312338 A1, 2009 ;
Location in patent: Page/Page column 60 ;
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 3.33333 h;
参考文献
SGX PHARMACEUTICALS, INC.
Patent: WO2006/15124 A2, 2006 ;
Location in patent: Page/Page column 103 ;
WO 2006/015124 A2
反应条件
1.1: N-iodo-succinimide / acetone / 4 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C
2.2: 3 h / 20 °C
View Scheme
参考文献
UNIVERSITY OF ROCHESTER; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; GELBARD, Harris A.; DEWHURST, Stephen; GENDELMAN, Howard E.
Patent: WO2014/85795 A1, 2014 ;
