2-溴-7-碘-5H-吡咯并[2,3-B]吡嗪合成路线 （共 4 条）
反应条件
iodine; potassium hydroxide in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere;
参考文献
EISAI R andamp; D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh
Patent: WO2010/15803 A1, 2010 ;
Location in patent: Page/Page column 43 ;
WO 2010/015803 A1
反应条件
1: pyridine / tetrahydrofuran / 96 h 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 75 °C 3: N-iodo-succinimide / acetone / 4 h / 20 °C View Scheme
参考文献
WO2011/149950 A2, ;
WO 2011/149950 A2
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 75 °C 2: N-iodo-succinimide / acetone / 4 h / 20 °C View Scheme
参考文献
WO2011/149950 A2, ;
WO 2011/149950 A2
反应条件
1: 2-bromo-7-iodo-5H-pyrrolo[3,2-b]pyrazine With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 0.333333 h;
2: p-toluenesulfonyl chloride in tetrahydrofuran; mineral oil
T=20°C; 3 h;
参考文献
UNIVERSITY OF ROCHESTER; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; GELBARD, Harris A.; DEWHURST, Stephen; GENDELMAN, Howard E.
Patent: WO2014/85795 A1, 2014 ;
Location in patent: Paragraph 0284 ;
