反应条件
1: 1.) LDA, 2.) PhSeBr, 3.) aq. H2O2, pyridine / 1) THF, -78 deg C, 0.5 h; 2) THF, -78 deg C; 3) CH2Cl2, rt, 1 h
2: 67 percent / LDA / hexamethylphosphoric acid triamide / 2 h / -78 °C
3: 1.) BH2Cl*SMe2, 2.) H2O, 3.) PCC / 1) CH2Cl2, rt, 2 h; 2) CH2Cl2, reflux, 0.5 h; 3) CH2Cl2, reflux, 3 h
4: 1.) TiCl4, Ti(OPr-i)4 / 1) Et2O, rt, 1 h; 2) Et2O, 0 deg C --> rt
5: 99 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature
6: Ph3P, diethyl azodicarboxylate / toluene / 9 h
View Scheme
参考文献
Kaisalo, Leena; Koskimies, Jorma; Hase, Tapio
Synthetic Communications, 1999 , vol. 29, # 3 p. 399 - 407
