5-乙氧基-1,3-苯并二恶茂合成路线 （共 5 条）
反应条件
N-bromosuccinmide in acetonitrile T=20°C; 0.5 h;
参考文献
CRYSTAX PHARMACEUTICALS, S.L.
Patent: WO2009/7399 A1, 2009 ;
Location in patent: Page/Page column 72-73 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 1.5 h;
参考文献
CRYSTAX PHARMACEUTICALS, S.L.
Patent: WO2009/7399 A1, 2009 ;
Location in patent: Page/Page column 72 ;
反应条件
1: 35 percent / 85percent formic acid; 30percent H2O2 / 16 h / 5 °C
2: anh. K2CO3 / acetone / 6 h / Heating
View Scheme
参考文献
Devakumar, C.; Saxena, V. S.; Mukerjee, S. K.
Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 725 - 730
反应条件
potassium carbonate in acetone
6 h; Heating;
参考文献
Devakumar, C.; Saxena, V. S.; Mukerjee, S. K.
Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 725 - 730
反应条件
1: 41 percent / Br2 / CCl4 / 2 h / 0 °C
2: 1.) 1.6 M n-BuLi in hexanes / 1.) ether, -78 deg C, 10 min, 2.) from -78 deg C to RT, 30 min
View Scheme
参考文献
Getahun, Zelleka; Jurd, Leonard; Chu, Ping S.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1058 - 1067
