N-(4-氨基苯基)-2-(吡咯烷-1-基)乙酰胺合成路线 （共 4 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate
P=1810.07 - 1965.21 Torr;
参考文献
Tala, Satishkumar D.; Ou, Tai-Hsin; Lin, Yi-Wen; Tala, Kiranben S.; Chao, Shu-Hsin; Wu, Ming-Hsi; Tsai, Tung-Hu; Kakadiya, Rajesh; Suman, Sharda; Chen, Ching-Huang; Lee, Te-Chang; Su, Tsann-Long
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 155 - 169
反应条件
1: 90 percent / Et3N / tetrahydrofuran / -15 - 20 °C
2: 82 percent / methanol / 0 - 20 °C
3: 70 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1: 82 percent / methanol / 0 - 20 °C
2: 70 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1: With hydrogenchloride; tert.-butylnitrite in tetrahydrofuran; water
1.5 h; Cooling with ice;
2: With sodium azide in tetrahydrofuran; water
T=20°C; Cooling with ice;
参考文献
Lombardo, Caterina Maria; Martinez, Iria Sanchez; Haider, Shozeb; Gabelica, Valerie; De Pauw, Edwin; Moses, John E.; Neidle, Stephen
Chemical Communications, 2010 , vol. 46, # 48 p. 9116 - 9118
